Peptide Chemistry

Over the past 25 years the Bradley group has employed peptide chemistry at the interface of medicine and chemistry from arrays to bacterial probes.

We have developed:

• Novel protecting group strategies (Jong 2015 )

• New coupling reagents (Valeur 2009 )

• New methods of peptide coupling using microwave irradiation (Diaz-Mochon 2008 )

We have synthesized large numbers of peptides (both natural and unnatural) for a multitude of applications ranging from:

• Fluorescent labelled microspheres and cell entry peptoids for cellular labelling and monitoring cell trafficking (Dhaliwal 2011 )

• Peptide probes for bacterial imaging (Akram 2015 )

• Substrates for proteases (Avlonitis 2013 )

• Tools for cellular delivery (Svensen 2012 )

• Scaffolds for cells

• We have also produced peptide libraries (including PNA encoded libraries) for kinase and protease analysis and other high-throughput screening applications (Svenson 2011 )