Over the past 25 years the Bradley group has employed peptide chemistry at the interface of medicine and chemistry from arrays to bacterial probes.
We have synthesized large numbers of peptides (both natural and unnatural) for a multitude of applications ranging from:
• Bimodal fluorogenic sensing of matrix proteolytic signatures in lung cancer (Megia-Fernandez, 2018 )
• Dendrimer substrates for proteases (Avlonitis, 2018 )
• Peptide probes for bacterial imaging (Akram, 2018 )
• Tools for cellular delivery (Svensen 2012 )
• Fluorescent labelled microspheres and cell entry peptoids for cellular labelling and monitoring cell trafficking (Dhaliwal 2011 )
• We have also produced peptide libraries (including PNA encoded libraries) for kinase and protease analysis and other high-throughput screening applications (Svenson 2011 )
We have developed:
• Novel protecting group strategies (Gambardella, 2018 )
• New coupling reagents (Valeur 2009 )
• New methods of peptide coupling using microwave irradiation (Diaz-Mochon 2008 )
• Scaffolds for cells