Curriculum Vitae - Professor Mark Bradley FRSE, FRSC

Present Position:

1997-2004   ..........    

1991- 1999   

1989-1991 

Professor of HT Chemical Biology, School of Chemistry, Edinburgh University.

Professorship and Director and Founder of the Combinatorial Centre of Excellence and Department of Chemistry, University of Southampton

Royal Society University Research Fellow, University of Southampton.

Lindemann Trust Postdoctoral Fellowship and SERC/NATO Postdoctoral Fellowship with Professor C.T. Walsh, Harvard Medical School, Boston, USA. 

Degrees:       

1986-1989

1982-1986

D.Phil. University of Oxford. Supervisor: Professor Sir J.E. Baldwin FRS.   

B. Sc. Oxford University, 1st Class Honors in Chemistry with Distinction in Biochemistry (Supplementary).

Selected Invited Presentations (of >250 total in past 10 years).

These can be divided into: (1). Award and named lectures; (2). International meetings (a). Plenary or (b). Keynote, (c). Others; (3). Educational and Public Service Lectures and (4). Organization of International Conferences.

(1). Award and Named Lectures:
(i).     Award of the Society of Combinatorial Sciences, Beijing, China 2009.
(ii).    Novartis Lectureship:  Boston, Basel, Tokyo, Vienna, Horsham, 2008.
(iii).   Merck Frosst Lecturership, Guelph, Canada, 2008.
(iv).   Leo Lectureship, Leo Pharmaceuticals, Award Lecture, Royal Danish School of Pharmacy, Copenhagen, Denmark, 2004.
(v).    Sigma-Aldrich Lectureship, Netherlands Science Foundation, Netherlands, 2006.
  
(2). International Meetings
(a). Plenary Lectures:
(i).     Japanese Society of Combinatorial Chemistry, Osaka, Japan, 2009.
(ii).    13th Brazilian Meeting on Organic Synthesis (BMOS), São Paulo, Brazil, 2009.
(iii).   Morten Meldal Symposium on "Molecular Recognition", Carlsberg Laboratory, Denmark 2009.
(iv).   Fifth SardiniaChem, 30th May, Sassari, Sardinia, 2008.
(v).    SCI Young Chemists Panel Introduction to Drug Discovery Chemistry, AZ Charnwood, Loughborough, UK, 2008 and GSK (Harlow) 2006.

(b). Keynote Lectures:
(i).     Med Chem Asia, Key-note and Session Chair Hyderabad, India, 2007.
(ii).    High-Throughput Organic Synthesis, Key-note and Session Chair Boston, USA, 2006.
(iii).   MedChem Europe 2006, Prague, Czechoslovakia, Keynote and Session Chair, 2006.
(iv).   European Society of Biomaterial, Brighton, 2004.
(v).    Ninth Tetrahedron Symposium, Challenges in Organic and Bioorganic Chemistry, Berkeley, USA, 2008.

(c). Other (and session chair):
(i).     Advances in Synthetic Chemistry, Herriot Watt, Invited & Session Chair, 2009.
(ii).    Ernst Schering Symposium "Emerging Technologies", symposium "New Avenues to Efficient Chemical Synthesis , Berlin, Invited, 2006.
(iii).   Advancing Library Design & Organic Synthesis, La Jolla, CA, Invited & Session Chair, 2004.       
(iv).   EuroCombi 2003, Copenhagen, Denmark. Invited & Session Chair 2003.
(v).    Laboratory Automation, Palm Springs, CA, USA, Invited & Session Chair, 2002.   

(3). Educational and Public Service Lectures.
(i).     Chemical Weapons Convention (CWC) workshop organised by IUPAC in Bergen, Norway, 2002.
(ii).    Innovative Combinatorial Approaches and Technologies - Practical Training Course, Florence, Italy, 2003.
(iii).   Summer Schools (with practical sessions) in Combinatorial Chemistry held (and organized) at Southampton University, UK, July 1999-2003.
(iv).   Introduction to Drug Discovery Chemistry – High-throughput Matters, Society of Chemistry Industry (for the Young Chemist Panel), 2007 and 2008, AstraZeneca (Charnwood) and GSK (Harlow). 
(v).    British Association for the Advancement of Science, Schools lecture, Southampton, UK, 2003.
(vi).   Lectures and workshops at Ramkamhange University, Burapha University and Chulabhron Research Institute, Thailand, 2003.
(vii). New Technologies in Chemistry, held (and organised) at Edinburgh University, UK, 2007 & 2008.
(viii). BASF, Internal Symposium (3 hour lecture), Germany, 2002.            
(ix).   High-throughput technologies for chemists (HTT4C). Organized by the RSC and the Chemistry Innovation Knowledge transfer partnership, Invited review lecture, Cambridge, UK, 2007.
(x).    Lecture courses on Combinatorial and High-Throughput Chemistry at multiple companies, e.g. Intervet (Vienna), GSK (Harlow), AZ (Gothenburg).

(4). Organization of International Conferences
(a). Main Organiser:
(i).     Chairman and organizer of EuroCombi3 (300 delegates, held in Winchester, UK in 2005).
(ii).    Chairman and organizer of New Technologies in Chemistry (Edinburgh, 2007 and 2008).  This international conference consisted of a series of symposiums and practical workshops.
(iii).   Chairman and organizer of Combinatorial Chemistry Summer Schools. These ran from 1999-2003 (Recognised by the RSC).
(b). Organising Committee:
(i).     Advances in Synthetic Chemistry, Herriot Watt, 2009
(ii).    Organizing Committee, EuroCombi4 Symposium, Florence, 2007.
(iii).   Organizing Committee, SCS Symposium, Beijing, 2009.
(iv).   Advancing Library Design & Organic Synthesis, La Jolla, CA, 2004.
(v).    EuroCombi 2003, Copenhagen, Denmark, 2003.
(v).    Laboratory Automation, Palm Springs, CA, USA, 2002.       
(iii).   High Throughput Organic Synthesis, Boston, MA, 2006.

International Prizes/Awards/Academy memberships:

2010

2009

Elected Fellow of the Royal Society of Chemistry.

SCS Award of the Society of Combinatorial Sciences. Awarded for the most significant scientific and technological advancement in the field of combinatorial sciences over the past 4 years. 

2008

2007...

Merck Frosst Lecturer 2008 at the Chemistry Department, University of Waterloo, Ontario, Canada. The Merck Lecture is sponsored by Merck Frosst (Montreal) with lectures at the company site in addition to the Chemistry Department at the Universiy of Waterloo.

Novartis Chemistry Lectureship Award. “This award was created to honor individuals for outstanding contributions in natural product synthesis and/or the development of synthetic methodology. The focus of the lectures is on synthetic organic chemistry to enhance the exposure of the Novartis chemical community to cutting edge chemistry”. The lectures are given at various Novartis research sites around the world throughout a selected year.

2006

2004

2003

2000

1999................

1998

1997

Netherlands Science Foundation, Sigma-Aldrich Lecturership, Netherlands.

Leo-Lectureship of Leo Pharma / TU Denmark

Royal Netherlands Academy of Arts and Science, Van’t Hoff lectureship prize.

Smith and Nephew Lectureship, University of York

Pfizer Award for Creativity in Organic Chemistry

Novartis Young Investigator Award (The Novartis Young Investigator Award  - presented annually to outstanding scientists under the age of 40 who are active in the areas of organic or bio-organic chemistry in the broadest sense).

Zeneca Research Award for Organic Chemistry. The Awards were initiated in 1990 to recognise the achievements of chemists in academia. The award is made each year to two European scientists who have made a significant contribution to the field of Organic Chemistry.

1992-2000

1989-1991

1989-1991

1989-1990

GlaxoWellcome Award for Innovative Chemistry.

Royal Society University Research Fellowship

SERC/NATO Post-Doctoral Fellowship

Lindemann Trust Post-Doctorial Fellowship

Publications: Professor Bradley’s group has published widely in the high-throughput, combinatorial and chemical biology areas with over 200 articles published in the form of peer reviewed papers, reviews and book chapters.

Selected Publications (2008-10):

(209). F. Khan, R.S. Tare, J.M. Kanczler, R.C. Oreffo, M. Bradley, Strategies for cell manipulation and skeletal tissue engineering using high-throughput polymer blend formulation and microarray techniques, Biomaterials 2010, 2216-2228.
(208). DNA Analysis by Dynamic Chemistry, F.R. Bowler, J-J. Diaz-Mochon, M.D. Swift, M. Bradley, Angew Chemie, 2010, 1809-1812.
(204). Microarrays of over 2000 hydrogels - Identification of substrates for cellular trapping and thermally triggered release, R. Zhang, A. Liberski, R. Sanchez-Martin, M. Bradley, Biomaterials, 2009, 6193-6201.
(207). Amide bond formation: beyond the myth of coupling reagents, E. Valeur, M. Bradley, Chemical Society Reviews, 2009, 606-631.
(206). Microsphere-Mediated Protein Delivery into Cells, R. Sanchez-Martin, L. Alexander, M. Muzerelle, J.M. Cardenas-Maestre, A. Tsakiridis, J.M. Brickman, M.Bradley, ChemBiochem, 2009, 1453-1456.
(205). A fluorescein-derived anthocyanidin-inspired pH sensor, A. Unciti-Broceta, M.R. Yusop, P.R. Richardson, J.G.A. Walton, M. Bradley, Tetrahedron Letters, 2009, Special Anniversary Issue: 3713-3715.
(203). Microspheres as a vehicle for biomolecule delivery to neural stem cells
N. Gennet, L.M. Alexander, R. Sanchez-Martin, J.M. Behrendt, A.J. Sutherland, J.M. Brickman, M. Bradley, M. Li, New Biotechnology, 2009,  442-449.
(202). Investigation of microsphere-mediated cellular delivery by chemical, microscopic and gene expression analysis, L.M. Alexander, S. Pernagallo, A. Livigni, J.M. Brickman, M. Bradley, Molecular Biosystems, 2010,  399-409.
(201). Laser printing mediated cell patterning A. Liberski, R. Zhang, M. Bradley, Chemical Communications, 2009, 7509-7511.
(200). Knocking (Anti)-Sense into Cells: The Microsphere Approach to Gene Silencing, L.M. Alexander, R.M. Sanchez-Martin, M. Bradley, Bioconj Chem., 2009, 422-426.
(199). Catch and release microwave mediated synthesis of cyanine dyes, M. Lopalco, E.N. Koini, J.K. Cho, M. Bradley, Org Biomol. Chem., 2009, 856-859.
(198). Microsphere-based tracing and molecular delivery in embryonic stem cells, A. Tsakiridis L.M. Alexander, N. Gennet R. Sanchez-Martin, A. Livigni, M. Li, M. Bradley, J.M. Brickman, Biomaterials, 2009, 5853-5861.
(197). Synthesis, penetrability and intracellular targeting of fluorescein-tagged peptoids and peptide-peptoid hybrids, A. Unciti-Broceta, F. Diezmann, C.Y. Ou-Yang, M. Bradley, Bioorg. Med.Chem, 2009, 959-966.
(196). Versatile Biocompatible Polymer Hydrogels: Scaffolds for Cell Growth, F. Khan, R.S. Tare, R. Oreffo, M. Bradley, Angew Chemie, 2009, 978-982.
(195). From 10,000 to 1: Selective synthesis and enzymatic evaluation of fluorescence resonance energy transfer peptides as specific substrates for chymopapain, J.J Diaz-Mochon, S. Planonth, M. Bradley, Anal Biochem., 2009, 101-105.
(194). Very long-chain fatty tails for enhanced transfection, A. Liberska, A. Unciti-Broceta, M. Bradley, Org BioMol Chem., 2009, 61-68.
(193). A microarray approach to the identification of polyurethanes for the isolation of human skeletal progenitor cells and augmentation of skeletal cell growth, R.S. Tare, F. Khan F, G. Tourniaire, M. Bradley, R. Oreffo, Biomaterials, 2009, 1045-1055.
(192). A cooperative polymer-DNA microarray approach to biomaterial investigation, S. Pernagallo, J.J. Diaz-Mochon, M. Bradley, Lab on a Chip, 2009, 397-403.
(191). Inkjet fabrication of polymer microarrays and grids-solving the evaporation problem, A. Liberski, R. Zhang R, M. Bradley, Chem. Commun 2009, 334-336
(190). Peptoid dendrimers - Microwave-assisted solid-phase synthesis and transfection agent evaluation, Juan J. Diaz-Mochon, Mario A. Fara, Rosario M. Sanchez-Martin, Mark Bradley, Tet. Lett. 2008, 49, 923-925.
(189). pH sensing in living cells using fluorescent microspheres, M. Bradley, L. Alexander, K. Duncan, M. Chennaoui, A. C. Jones, and R.M. Sanchez-Martin, Bioorg. Med. Chem. Lett. 2008, 18, 313-317.

(188). Multi-functionalized Biocompatible Microspheres for Sensing, R. M. Sánchez-Martín, L. Alexander and M. Bradley, Ann.N.Y.Acad.Sci., 2008, 207-217 (Fluorescence Methods And Applications: Spectroscopy, Imaging, And Probes). 
(187). High-throughput and design of experiment mediated optimization of pigment based ink formulations, J.M. Lopez-Pedrosa, M. Bradley, Pigment and Resin Technology 2008, 094102.  
(186). Combining Nebulization-Mediated Transfection and Polymer Microarrays for the Rapid Determination of Optimal Transfection Substrates, A. Unciti-Broceta, J.J. Diaz-Mochon, H. Mizomoto, M. Bradley, J. Comb. Chem, 2008, 10, 179-184.
(185). Screening for polymorphs on polymer microarrays, A.R. Liberski, G.J.  Tizzard, J.J.Diaz-Mochon, M.B. Hursthouse, P. Milnes, M. Bradley, M J. Comb. Chem, 2008, 10, 24-27.
(184). Inkjet Fabrication of Hydrogel Microarrays Using in situ Nanolitre-scale Polymerisation, Rong Zhang, Albert Liberski, Ferdous Khan, Juan Jose Diaz-Mochon and Mark Bradley, Chem. Commun 2008, 1317-1319.
(183). Cellular uptake of fluorescent labelled biotin-streptavidin microspheres, M. Bradley, L. Alexander and R. M. Sánchez-Martín, J. Fluoresc., 2008 doi: 10.1007/s10895-008-0334-1.
(182). Deciphering cellular morphology and biocompatibility using polymer microarrays, S. Pernagallo, A. Unciti-Broceta, J.J. Díaz-Mochón, M. Bradley, 2008, Biomed. Mater. 3, 034112, doi:10.1088/1748-6041/3/3/034112.
(181). Synthesis, penetrability and intracellular targeting of fluorescein-tagged peptoids and peptide–peptoid hybrids, Unciti-Broceta A, Diezmann F, Ou-Yang CY, Fara MA, Bradley M, Bioorg Med Chem. 2008, doi:10.1016/j.bmc.2008.02.068
(180). Dunking Doughnuts into Cells - Selective Cellular Translocation and In Vivo Analysis of Polymeric Micro-Doughnuts, Alexander L, Dhaliwal K, Simpson J, Bradley M, Chem. Comm. 2008, 3507-3509.
(I am happy to supply the full list upon request)

Patents: The following (selected patents) have been granted or are currently going through PCT or filed.

(i).        WO9931049: Neuroprotective Agents: Pringle Ashley; Bradley Mark; Sundstrom Lars; Iannotti Fausto (Granted, Licensed to Hunter-Flemming).

(ii).       WO2006016163: Polymers Useful As Medical Materials, Bradley Mark; Mizomoto Hitoshi (in National Phase, Asahi Kasei, Licensed to Ilika Technologies).

(iii).      WO2007113531: Topical Drug Delivery, Healy Eugene; Friedmann Peter; Bradley Mark (in National Phase).

(iv).      WO2005113136: Leukocyte Adsorbing Material: Bradley Mark; Shishido Junichi; Thaburet Jean-Francois (in National Phase, with Asahi Technologies).

(V).      WO2008047160: Copolymers Suitable For Use In Corneal Bandages: Tourniaire Guilhem; Bradley Mark; Liberski Albert (in National phase, Licensed to Ilika Technologies).

(vi).      WO03014743: Use of dendrimers and poly-branched molecules to enhance signal in fluorescent assay systems, Hamilton Alan; Bradley Mark; Ellard John; Cummins William; Briggs Mark; Zollitsch Thomas (National Phase with Amersham/GE).

(vii).     WO2006082352: Modified Pigments: Pitt Alan, Goddard John, Bradley Mark, Ronot Anais, Simister Elizabeth (with Kodak).

(vii).     WO2009050483: Cationic Lipids, Unciti-Broceta Asier; Bradley Mark, (National Phase).

(viii).    WO2009037473: Nucleobase Characterisation: Bradley Mark; Diaz-Mochon Juan (in National Phase).

(ix).      WO9932705 Solid Support Materials Kobylecki Ryszard; Kronfli Esam; Bradley Mark; Cowell Daniel (with Cambridge Combinatorial Ltd).

(x).       WO2005036149, Measurement Of Melting Points Of Multiple Samples Bradley Mark; Thaburet Jean-Francois (in National phase, Licensed to Ilika Technologies).

Funding

Current Funding ID. The Bradley research group currently consists of the PI and 30 researchers (15 PhDs and 15 postdoctoral research associates (PDRAs) and is composed of some 17 nationalities (Finland, France, Denmark, Germany, Greece, Italy, Poland, Spain, Sweden, UK, Bangladesh, Canada, China, India, Lebanon, Malaysia, Thailand).

Research Grants:
(a). Currently-active research grants (Bradley as Principal Investigator):
(EPSRC = Engineering and Physical Sciences Research Council, MRC  = Medical Research Council, BBSRC = Biotechnology and Biological Sciences Research Council)

• PI: April 2005-Sept 2010 (EPSRC) Title: High- Throughput Chemical Biology for Efficient Cellular Delivery: £420k (with Professor Healey (Clinical dermatologist) and Professor Elliott (Cancer cell biologist).
• PI: Mar 2007-Aug 2011 (EPSRC) Title: Post-Coded Ligands for Cell Sorting and Delivery: £738k.
• PI: Dec 2008-Nov 2011 (ITI Life Sciences) Title: Ubiquitination: £1.5m for Bradley group (with Professor Tyers and Walkinshaw).
• PI: Jul 2009-Jun 2012 (EU HEALTH-2007-1.4-7) Title: Bio-chemically Equivalent Substitutive Technology for Stem Cells (BEST) (coordinator: Dr DeSousa): £334k for Bradley group.
• PI: Feb 2009 Aug 2010 (BBSRC) Title: Biodegradable polymer scaffolds for functional bone repair: £172k (with Professor Oreffo (regenerative medicine)).
• PI: May 2008-April 2010 (Ilika Technologies) Title: Confidential: £260k.
• PI: Oct 2009-Sept 2012 (MRC) Title: Mutiplexed in vivo Optimisation of Non-Toxic Gene Transfer Agents: £743k (with Drs Boyd and McLachlan (Cystic fibrosis gene therapy)).
• PI: Dec 2009-Oct 2011 (MRC) Title: Functional Optical Imaging in Mice and Man: £625k (with Professor Haslett (Clinician in lung infection, with research interests in optical imaging).
• PI: Jan 2010-Dec 2010 (EPSRC) Title: Bio-Active Polymer Driven Cell Based Systems - Predicting Human Drug Toxicity: £245 (with Dr Hay (Stem cell hepatocyte biologist)).
• PI: Aug 2008-July 2010 (Scottish Enterprise – Proof of concept grant (translational award) (PoC)) Title: Novel Methods of DNA Analysis: £280k.

(b). Currently-active research grants (Bradley as Co-Applicant):

• Co-Applicant: Sept 2009 – Aug 2012 (MRC) Title: Multimodal Smart Imaging of Critical Inflammatory Processes in Murine Models of Pulmonary Fibrosis: £749k (£350k to Bradley). PI is Professor Haslett.
• Co-Applicant: Jan 2009-Dec 2012 (MRC) Title: The Biologically Effective Dose for the Pro-Inflammatory Effects of Nanoparticles in Lung Target Cells: £551K (£120k to Bradley). PI is Professor Ken Donaldson (world authority on particle toxicity).
• Co-Applicant: Jan 2009-Dec 2013 (Center for Translational Molecular Medicine (CTMM) – Funded by the Dutch Government: (£220K to Bradley). The Bradley group is the only non-Dutch collaborator in the whole of the CTMM programme.
• Co-Applicant: 2006-2014) (CRUK) Title: Cancer Medicinal Chemistry Training Centre: (Coordinator: A Hulme, Edinburgh) £1.2m.
• Co-Applicant: Sep 2006-Aug 2010 (EU) EC-Mest-Ct-2005-020744 Synthesis Training for a Chemical Biology Approach to Drug Design (Coordinator: A Hulme, Edinburgh): £807k.

PhD Students graduating from the group (and nationality) since 2000.
2001    Bordin Chitkul (Thailand); Sunil Rana  (UK).
2002    David Sampson (UK); Iain Linguard (UK); Sean Monaghan (Ireland); Loic LeStrat (France); Sonia Alesso (Italy).
2003    Cecile Vitre (France); Mitzio Matteucci (Italy); James Merrigton (UK); Boonek Yingyongnarongkul (Thailand), Carole Carmody (France).
2004    Hitoshi Mixomoto (Japan); Karin Johnson (Sweden); Mark Dixon (UK); Cathryn McMamara (UK); Delphine Launay (France).
2005    Siew-Eng How (Malaysia); Lu Shin Wong (UK); Nicola Galaffu (Italy); A. Jasmine Jose (India).
2006    Carole Bruckler (Luxemburg); Eric Valeur (France); Anais Ronot (France).
2007    Raman Najman (France); Guilheim Tourniaire (France); Toby Cull (UK).
2008    Philip Milnes (UK); Maria Lopalco (Italy); Christophe Portal (France), Antonio Fara (Italy).
2009    Gianluca Sechi (Italy); Albert Liberski (Poland); Lois Alexander (UK); Delphine Pouchain (France); Jose Lopez-Pedrosa (Spain).
(from a total of 48 since 1996)

Some other Activities:

2009: International Reviewer for the Helmholtz Programmes (equiv. German Research Council).

2000-2009: European Editor of the American Chemical Society: Journal of Combinatorial Chemistry.

NIH, EPSRC and BBSRC Panel member. Reviewer for many international research councils (France, Austria, Sweden, Switzerland, USA, Hong Kong).

MRC Panel of Experts.

• Board Member of the Faraday program: Insight. Board Member of the Faraday program: Insight. (DTI/EPSRC initiative to promote the development and exploitation of High Throughput Technologies (HTT) for product and process development for the benefit of UK industry and the Science, Engineering and Technology (SET) base and to encourage closer contact between academia and UK industry).
• Consultant for many companies over the past decade.
• Founder member of the European Society for Combinatorial Sciences (1997) – Aims: Education in combinatorial sciences across the EU.
• 2001-2006RS Member on the standing committee on Scientific Aspects of International Security (SAIS).
• Involvement with the start-up of Cambridge Combinatorial (bought by Millennium Pharmaceuticals in 2001, Hunter-Fleming (Neuroprotection company).
• Co-Founder of Ilika Technologies (May 2004).